What's the prognosis for Bill?

Meet Bill

Bill - Lack of Deep Molecular Response Bill - Lack of Deep Molecular Response

Meet Bill

  • 65 years of age
  • Diagnosed with Ph+ CML 3 years ago
  • Treated with a TKI since diagnosis
  • Not tested at the 3-month milestone
  • Achieved CCyR at 12 months; continues to get tested with IS RQ-PCR every 6 months
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Ph+ CML, Philadelphia chromosome–positive chronic myeloid leukemia; TKI, tyrosine kinase inhibitor; CCyR, complete cytogenetic response; IS, International Scale; RQ-PCR, real-time quantitative polymerase chain reaction; mRNA, messenger ribonucleic acid; MMR, major molecular response; Dx, diagnosis; AP/BC, accelerated phase or blast crisis.

References: 1. Marin D, Ibrahim AR, Lucas C, et al. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol. 2012;30(3):232-238. 2. Referenced with permission from the NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) for Chronic Myeloid Leukemia V.2.2017. © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed March 1,2017. To view the most recent and complete version of the guideline, go online to NCCN.org.