In patients with Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML)

Deep molecular responses may have significant prognostic value1

Deep molecular response (≤0.1% IS BCR-ABL mRNA) at 18 months is associated with higher rates of1*:

EFS, Event-Free Survival
PFS, Progression-Free Survival

In a retrospective analysis comparing long-term outcomes between patients achieving and failing to achieve deep molecular response, those patients with MMR at 18 months had higher rates of EFS (95% vs 75%) and PFS (99% vs 90%).1

Prognostic value of deep response in CML treatment Prognostic value of deep response in CML treatment

International Scale (IS) RQ-PCR monitoring can detect early and deep molecular response1,2

  • MMR can be assessed on the International Scale1
  • IS RQ-PCR has the capability to monitor responses after patients have achieved CCyR3
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*Compared with total no MMR population (>0.1% IS BCR-ABL mRNA).

Compared with patients whose BCR-ABL levels were >0.1% to ≤1.0% IS.

mRNA, messenger ribonucleic acid; MMR, major molecular response; RQ-PCR, real-time quantitative polymerase chain reaction; CCyR, complete cytogenetic response.

References: 1. Hughes TP, Hochhaus A, Branford S, et al. Blood. 2010;116(19):3758-3765. 2. Marin D, Ibrahim AR, Lucas C, et al. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors. J Clin Oncol. 2012;30(3):232-238. 3. Referenced with permission from the NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) for Chronic Myeloid Leukemia V.2.2017. © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed March 1, 2017. To view the most recent and complete version of the guideline, go online to NCCN.org.