What should be done about Louis' rising BCR-ABL levels?

Meet Louis

Louis - Rising BCR-ABL Levels Louis - Rising BCR-ABL Levels

Meet Louis

  • 54 years of age
  • Diagnosed with Ph+ CML 2 years ago
  • Treated with a TKI since diagnosis
  • BCR-ABL levels are rising after 1 year of maintaining MMR
  • Monitored by IS-standardized RQ-PCR
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Ph+ CML, Philadelphia chromosome–positive chronic myeloid leukemia; TKI, tyrosine kinase inhibitor; MMR, major molecular response; IS, International Scale; RQ-PCR, real-time quantitative polymerase chain reaction; mRNA, messenger ribonucleic acid; CCyR, complete cytogenetic response; Dx, diagnosis.

References: 1. Jabbour EJ, Quintás-Cardama A. Molecular monitoring 101: helping your patients with chronic myeloid leukemia to understand the meaning of molecular response. Leuk Lymphoma. 2012;53(8):1452-1460. 2. Referenced with permission from the NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) for Chronic Myeloid Leukemia V.2.2017. © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed March 1, 2017. To view the most recent and complete version of the guideline, go online to NCCN.org.